PIM Kinase Inhibitors Downregulate STAT3Tyr705 Phosphorylation
نویسندگان
چکیده
منابع مشابه
apeutic Discovery Kinase Inhibitors Downregulate Ther T 3 Tyr 705 Phosphorylation
ownload g a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell h and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differactivity on cancer versus normal cells. Introduction of structural modifications yielded compound , which inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ...
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ownload g a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell h and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differactivity on cancer versus normal cells. Introduction of structural modifications yielded compound , which inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ...
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Previous studies from our laboratory showed that p21 can be phosphorylated by Pim-1 kinase in vitro , implying that part of the function of Pim-1 might involve influencing the cell cycle. In the present study, site-directed mutagenesis and phosphorylated-specific antibodies were used as tools to identify the sites phosphorylated by Pim-1 and the consequences of this phosphorylation. What we fou...
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Pim-1 is a proto-oncogene that encodes a serine/threonine kinase that is overexpressed in a range of haematopoietic malignancies and solid cancers. Pim-1 expression is tightly regulated by multiple biomolecules at different levels. Several lines of evidence have indicated that dysregulation of Pim-1 can interfere with the cell cycle and apoptosis to promote malignant transformation of a number ...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2010
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-10-0321